@article{74956e5200f14632917adeae1f1233f5,
title = "Deciphering the dynamic code: DNA recognition by transcription factors in the ever-changing genome",
abstract = "Transcription factors (TFs) intricately navigate the vast genomic landscape to locate and bind specific DNA sequences for the regulation of gene expression programs. These interactions occur within a dynamic cellular environment, where both DNA and TF proteins experience continual chemical and structural perturbations, including epigenetic modifications, DNA damage, mechanical stress, and post-translational modifications (PTMs). While many of these factors impact TF-DNA binding interactions, understanding their effects remains challenging and incomplete. This review explores the existing literature on these dynamic changes and their potential impact on TF-DNA interactions.",
keywords = "DNA, DNA damage, DNA mechanics, epigenetic modification, protein-DNA interaction, repair enzyme, transcription factor",
author = "Yao, {Yumi Minyi} and Irina Miodownik and O{\textquoteright}Hagan, {Michael P.} and Muhammad Jbara and Ariel Afek",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2024",
doi = "10.1080/21541264.2024.2379161",
language = "אנגלית",
volume = "15",
pages = "114--138",
journal = "Transcription",
issn = "2154-1264",
publisher = "Taylor and Francis Ltd.",
number = "3-5",
}