Deciphering the Biological Activities of Antifungal Agents with Chemical Probes

Micha Fridman*, Kaori Sakurai*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

The growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these microorganisms pose to animal and human health and global food security. Open questions remain regarding the mechanisms of action of the limited repertoire of antifungal agents, making it challenging to rationally develop more efficacious therapeutics. In recent years, the use of chemical biology approaches has resolved some of these questions and has provided new promising concepts to guide the design of antifungal agents. By focusing on examples from studies carried out in recent years, this minireview describes the key roles that probes based on antifungal agents and their derivatives have played in uncovering details about their activities, in detecting resistance, and in characterizing the interactions between these agents and their targets.

Original languageEnglish
Article numbere202211927
JournalAngewandte Chemie - International Edition
Volume62
Issue number12
DOIs
StatePublished - 13 Mar 2023

Funding

FundersFunder number
ACBI
Japan Society for the Promotion of Science17H06110, 18K05331
Israel Science Foundation179/19

    Keywords

    • Antifungal Agents
    • Antifungal Mode of Action
    • Chemical Probes
    • Fluorescent Labeling

    Fingerprint

    Dive into the research topics of 'Deciphering the Biological Activities of Antifungal Agents with Chemical Probes'. Together they form a unique fingerprint.

    Cite this