Deamination of histamine by peroxidase of neutrophils and eosinophils

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Abstract

The enzymatic activity of guinea pig myeloperoxidase (MPO) and eosinophil peroxidase (EP) was compared on the following substrates: guaiacol, aspartic acid and histamine. EP manifested a 4 fold activity per cell compared with MPO in peroxidation of guaiacol. The ability of PMN to degrade aspartic acid by peroxidative deamination was confirmed and the ability to degrade histamine established. Eosinophils, however, showed no activity on both substrates despite their known antihistaminic properties.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalRES Journal of the Reticuloendothelial Society
Volume17
Issue number3
StatePublished - 1975

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