De novo purine synthesis in skeletal muscle

S. Brosh, P. Boer, E. Zoref-Shani, O. Sperling*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Myoblast and primary muscle cultures from rat were found to contain the complete pathway of de novo purine nucleotide synthesis. Quantitative assessment of the pathway in skeletal muscle in mice in vivo, revealed a more intensive purine production in muscle than in liver. Skeletal muscle is thus a major site of de novo purine production in the mammalian body.

Original languageEnglish
Pages (from-to)181-183
Number of pages3
JournalBiochimica et Biophysica Acta - General Subjects
Issue number1
StatePublished - 12 Jan 1982


  • Cell culture (Skeletal muscle)
  • Purine nucleotide synthesis


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