DCC protein expression in clear cell renal cell carcinoma

Y. Dekel, V. Kugel, P. M. Livne, R. Gal, R. Koren

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To investigate whether the expression of protein from the 'deleted in colorectal cancer' (DCC) gene, which predicts a poor outcome for patients with colorectal carcinoma, can also serve as a prognostic factor in renal cell carcinoma (RCC). PATIENTS AND METHODS: The expression of DCC was evaluated immunohistochemically in 94 paraffin-embedded tumour samples from patients with stage T1, T2, and T3 clear cell RCC. The mean follow-up was 52.3 months. The endpoints of the study were recurrence of disease and death from disease. RESULTS: The under-expression of DCC protein was detected in 63% of patients who died from the disease and in 36% with no evidence of disease. DCC protein under-expression was detected in all patients with T1 tumours who died from the disease, in half the T2 tumours and in two-thirds of T3 tumours. CONCLUSION: DCC protein under-expression correlated with more aggressive tumour behaviour and a greater risk of death from RCC. However, a larger cohort of patients should be assessed before drawing definitive conclusions.

Original languageEnglish
Pages (from-to)867-869
Number of pages3
JournalBJU International
Volume93
Issue number6
DOIs
StatePublished - Apr 2004

Keywords

  • DCC expression
  • Prognosis
  • RCC
  • Survival

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