Data From a One-Stop-Shop Comprehensive Cancer Screening Center

Ezra Bernstein, Shahar Lev-Ari, Shiran Shapira, Ari Leshno, Udi Sommer, Humaid Al-Shamsi, Meital Shaked, Ori Segal, Lior Galazan, Mori Hay-Levy, Miri Sror, Amira Harlap-Gat, Michael Peer, Menachem Moshkowitz, Ido Wolf, Eliezer Liberman, Gil Shenberg, Eyal Gur, Hanoch Elran, Gustavo MelingerJacob Mashiah, Ofer Isakov, Elad Zrifin, Nathan Gluck, Roy Dekel, Shlomi Kleinman, Galit Aviram, Arye Blachar, Ada Kessler, Orit Golan, Ravit Geva, Ofer Yossepowitch, Alfred I. Neugut, Nadir Arber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


PURPOSECancer is the second leading cause of death globally. However, by implementing evidence-based prevention strategies, 30%-50% of cancers can be detected early with improved outcomes. At the integrated cancer prevention center (ICPC), we aimed to increase early detection by screening for multiple cancers during one visit.METHODSSelf-referred asymptomatic individuals, age 20-80 years, were included prospectively. Clinical, laboratory, and epidemiological data were obtained by multiple specialists, and further testing was obtained based on symptoms, family history, individual risk factors, and abnormalities identified during the visit. Follow-up recommendations and diagnoses were given as appropriate.RESULTSBetween January 1, 2006, and December 31, 2019, 8,618 men and 8,486 women, average age 47.11 ± 11.71 years, were screened. Of 259 cancers detected through the ICPC, 49 (19.8%) were stage 0, 113 (45.6%) stage I, 30 (12.1%) stage II, 25 (10.1%) stage III, and 31(12.5%) stage IV. Seventeen cancers were missed, six of which were within the scope of the ICPC. Compared with the Israeli registry, at the ICPC, less cancers were diagnosed at a metastatic stage for breast (none v 3.7%), lung (6.7% v 11.4%), colon (20.0% v 46.2%), prostate (5.6% v 10.5%), and cervical/uterine (none v 8.5%) cancers. When compared with the average stage of detection in the United States, detection was earlier for breast, lung, prostate, and female reproductive cancers. Patient satisfaction rate was 8.35 ± 1.85 (scale 1-10).CONCLUSIONWe present a proof of concept study for a one-stop-shop approach to cancer screening in a multidisciplinary outpatient clinic. We successfully detected cancers at an early stage, which has the potential to reduce morbidity and mortality as well as offer substantial cost savings.

Original languageEnglish
Pages (from-to)2503-2510
Number of pages8
JournalJournal of Clinical Oncology
Issue number14
StatePublished - 10 May 2023


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