DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

Galina M. Proshkina, Elena I. Shramova, Marya V. Shilova, Ivan V. Zelepukin, Victoria O. Shipunova, Anastasia V. Ryabova, Sergey M. Deyev, Alexander B. Kotlyar

Research output: Contribution to journalArticlepeer-review

Abstract

Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

Original languageEnglish
Article number5235
JournalCancers
Volume13
Issue number20
DOIs
StatePublished - 1 Oct 2021

Keywords

  • Cancer
  • DARPin
  • Gold nanorods
  • Mice treatment
  • Near-infrared illumination
  • Photothermal therapy

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