TY - JOUR
T1 - DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice
AU - Proshkina, Galina M.
AU - Shramova, Elena I.
AU - Shilova, Marya V.
AU - Zelepukin, Ivan V.
AU - Shipunova, Victoria O.
AU - Ryabova, Anastasia V.
AU - Deyev, Sergey M.
AU - Kotlyar, Alexander B.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
AB - Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.
KW - Cancer
KW - DARPin
KW - Gold nanorods
KW - Mice treatment
KW - Near-infrared illumination
KW - Photothermal therapy
UR - http://www.scopus.com/inward/record.url?scp=85117177418&partnerID=8YFLogxK
U2 - 10.3390/cancers13205235
DO - 10.3390/cancers13205235
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C2 - 34680384
AN - SCOPUS:85117177418
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 20
M1 - 5235
ER -