DARPin_9-29-targeted gold nanorods selectively suppress her2-positive tumor growth in mice

Galina M. Proshkina, Elena I. Shramova, Marya V. Shilova, Ivan V. Zelepukin, Victoria O. Shipunova, Anastasia V. Ryabova, Sergey M. Deyev*, Alexander B. Kotlyar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Near-infrared phototherapy has great therapeutic potential for cancer treatment. How-ever, for efficient application, in vivo photothermal agents should demonstrate excellent stability in blood and targeted delivery to pathological tissue. Here, we demonstrated that stable bovine serum albumin-coated gold mini nanorods conjugated to a HER2-specific designed ankyrin repeat protein, DARPin_9-29, selectively accumulate in HER2-positive xenograft tumors in mice and lead to a strong reduction in the tumor size when being illuminated with near-infrared light. The results pave the way for the development of novel DARPin-based targeted photothermal therapy of cancer.

Original languageEnglish
Article number5235
JournalCancers
Volume13
Issue number20
DOIs
StatePublished - 1 Oct 2021

Funding

FundersFunder number
GNR
Russian Foundation for Basic Research19-54-06001
Ministry of Science and Technology, Israel3-16495
Russian Science Foundation21-74-30016

    Keywords

    • Cancer
    • DARPin
    • Gold nanorods
    • Mice treatment
    • Near-infrared illumination
    • Photothermal therapy

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