Dancing genomes: Fungal nuclear positioning

Amy Gladfelter, Judith Berman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The many different mechanisms that fungi use to transmit and share genetic material are mediated by a broad range of chromosome and nuclear dynamics. The mechanics underlying nuclear migration are well integrated into detailed models, in which the forces supplied by plus- and minus-end-directed microtubule motors position and move the nucleus in a cell. Although we know much about how cells move nuclei, we know much less about why the cell invests in so many different nuclear 'dances'. Here, we briefly survey the available models for the mechanics of nuclear migration in fungi and then focus on examples of how fungal cells use these nuclear dances - the movement of intact nuclei in and between cells - to control the integrity, ploidy and assortment of specific genomes or individual chromosomes.

Original languageEnglish
Pages (from-to)875-886
Number of pages12
JournalNature Reviews Microbiology
Volume7
Issue number12
DOIs
StatePublished - 2009
Externally publishedYes

Funding

FundersFunder number
National Science FoundationMCB-0719126
National Institutes of HealthR01 DE14666, R01AI0624273
National Institute of Allergy and Infectious DiseasesR01AI075096
March of Dimes Foundation

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