TY - JOUR
T1 - Dactinomycin potentiation of radiation pneumonitis
T2 - A forgotten interaction
AU - Cohen, Ian J.
AU - Loven, David
AU - Schoenfeld, Tommy
AU - Sandbank, Judith
AU - Kaplinsky, Chaim
AU - Yaniv, Yitzchak
AU - Jaber, Lutfi
AU - Zaizov, Rina
PY - 1991
Y1 - 1991
N2 - No mention of dactinomycin potentiation of pulmonary radiation was found in a review of the literature of the past 12 years. Before that, this complication was well described and investigators had calculated that dactinomycin increased the toxic effect of lung radiation by a factor of 1.3 and reduced the radiation tolerance of the lung by at least 20% An example of such a toxic effect is described in the treatment of a 7-year-old girl with lung metastases from Ewing's sarcoma. The chemotherapy protocol followed contained cyclophosphamide, vincristine, dactinomycin, adriamycin, cisplatinum, VP16, and radiotherapy. The treatment was associated with fatal pulmonary fibrosis following the reintroduction of dactinomycin after radiotherapy. Our experience suggests that there is clinical significance to this complication in sarcoma therapy when dactinomycin-containing protocols are used with radiation in the treatment of pulmonary metastases.
AB - No mention of dactinomycin potentiation of pulmonary radiation was found in a review of the literature of the past 12 years. Before that, this complication was well described and investigators had calculated that dactinomycin increased the toxic effect of lung radiation by a factor of 1.3 and reduced the radiation tolerance of the lung by at least 20% An example of such a toxic effect is described in the treatment of a 7-year-old girl with lung metastases from Ewing's sarcoma. The chemotherapy protocol followed contained cyclophosphamide, vincristine, dactinomycin, adriamycin, cisplatinum, VP16, and radiotherapy. The treatment was associated with fatal pulmonary fibrosis following the reintroduction of dactinomycin after radiotherapy. Our experience suggests that there is clinical significance to this complication in sarcoma therapy when dactinomycin-containing protocols are used with radiation in the treatment of pulmonary metastases.
KW - Dactinomycin
KW - Pulmonary toxicity
KW - Radiation
UR - http://www.scopus.com/inward/record.url?scp=0025853228&partnerID=8YFLogxK
U2 - 10.3109/08880019109033447
DO - 10.3109/08880019109033447
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AN - SCOPUS:0025853228
VL - 8
SP - 187
EP - 192
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 2
ER -