TY - JOUR
T1 - Cytotoxicity of B72.3XOKT3 bispecific antibody recognizing human colon cancer
AU - Shpitz, Baruch
AU - Stern, Hartley
AU - Sandhu, Jas S.
AU - Reilley, Raymond M.
AU - Tropak, Michael B.
AU - Jansz, Gwen
AU - Xu, Jennis
AU - Gallinger, Steven
N1 - Funding Information:
1Supported by Lederman Cancer Research Fund and American Physician Fellowship.
PY - 1996/2/15
Y1 - 1996/2/15
N2 - Bispecific monoclonal antibodies can be used to redirect peripheral blood lymphocytes against tumor cells. In the present study, a murine bispecific monoclonal antibody was developed using somatic hybridization. The antibody has two different binding arms: one arm directed against human CD3 receptor expressed on T-lymphocytes and the other against tumor associated glycoprotein TAG-72, expressed on human carcinomas, such as colon, breast, and pancreas. Partially purified antibody was capable of inducing human T- cell proliferation and preventing growth of colon cancer cell line in nu/nu mice in a tumor neutralization assay.
AB - Bispecific monoclonal antibodies can be used to redirect peripheral blood lymphocytes against tumor cells. In the present study, a murine bispecific monoclonal antibody was developed using somatic hybridization. The antibody has two different binding arms: one arm directed against human CD3 receptor expressed on T-lymphocytes and the other against tumor associated glycoprotein TAG-72, expressed on human carcinomas, such as colon, breast, and pancreas. Partially purified antibody was capable of inducing human T- cell proliferation and preventing growth of colon cancer cell line in nu/nu mice in a tumor neutralization assay.
UR - https://www.scopus.com/pages/publications/0030040898
U2 - 10.1006/jsre.1996.0093
DO - 10.1006/jsre.1996.0093
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AN - SCOPUS:0030040898
SN - 0022-4804
VL - 61
SP - 134
EP - 138
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 1
ER -
