Cytosolic calcium in platelets of spontaneously hypertensive rats

Reuven Zimlichman*, David S. Goldstein, Shulamit Zimlichman, Harry R. Keiser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i(thrombin, adenosine diphosphate, serotonin and ionomycin). Despite clear-cut changes in [Ca2+]i during these manipulations, there were no differences between the SHR and WKY rats in baseline levels of [Ca2+]i or in the kinetics of changes in [Ca2+]i. These results do not support the hypothesis that high levels of [Ca2+]i at rest or abnormal kinetics of changes in [Ca2+]i play a pathophysiological role in the hypertension of SHR.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalJournal of Hypertension
Issue number3
StatePublished - Jun 1986
Externally publishedYes


  • Free intracellular calcium
  • Platelets
  • Quin 2
  • Spontaneously hypertensive rats


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