TY - JOUR
T1 - Cytosolic calcium in platelets of spontaneously hypertensive rats
AU - Zimlichman, Reuven
AU - Goldstein, David S.
AU - Zimlichman, Shulamit
AU - Keiser, Harry R.
PY - 1986/6
Y1 - 1986/6
N2 - To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i(thrombin, adenosine diphosphate, serotonin and ionomycin). Despite clear-cut changes in [Ca2+]i during these manipulations, there were no differences between the SHR and WKY rats in baseline levels of [Ca2+]i or in the kinetics of changes in [Ca2+]i. These results do not support the hypothesis that high levels of [Ca2+]i at rest or abnormal kinetics of changes in [Ca2+]i play a pathophysiological role in the hypertension of SHR.
AB - To test the hypothesis that an abnormality of the intracellular concentration of ionized calcium, [Ca2+]i, is associated with high blood pressure, we measured [Ca2+]i in the platelets of spontaneously hypertensive (SHR) and Wistar-Kyoto control (WKY) rats using the Quin 2 technique after separation of the platelets in calcium-free medium, during calcium repletion, and upon exposure to agonists which increase platelet [Ca2+]i(thrombin, adenosine diphosphate, serotonin and ionomycin). Despite clear-cut changes in [Ca2+]i during these manipulations, there were no differences between the SHR and WKY rats in baseline levels of [Ca2+]i or in the kinetics of changes in [Ca2+]i. These results do not support the hypothesis that high levels of [Ca2+]i at rest or abnormal kinetics of changes in [Ca2+]i play a pathophysiological role in the hypertension of SHR.
KW - Free intracellular calcium
KW - Platelets
KW - Quin 2
KW - Spontaneously hypertensive rats
UR - http://www.scopus.com/inward/record.url?scp=0022525504&partnerID=8YFLogxK
U2 - 10.1097/00004872-198606000-00005
DO - 10.1097/00004872-198606000-00005
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AN - SCOPUS:0022525504
SN - 0263-6352
VL - 4
SP - 283
EP - 287
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 3
ER -