TY - JOUR
T1 - Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for disseminated intra-abdominal malignancies in children—a single-institution experience
AU - Zmora, Osnat
AU - Hayes-Jordan, Andrea
AU - Nissan, Aviram
AU - Kventsel, Iris
AU - Newmann, Yoram
AU - Itskovsky, Kira
AU - Ash, Shifra
AU - Levy-Mendelovich, Sarina
AU - Shinhar, Daniel
AU - Ben-Yaakov, Almog
AU - Toren, Amos
AU - Bilik, Ron
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/7
Y1 - 2018/7
N2 - Purpose: Our purpose was to present our institutional experience with performing complete cytoreduction surgery and heated intraoperative chemotherapy (CRS-HIPEC) for children with disseminated intraabdominal malignancies, guided by a leading international center performing CRS-HIPEC in children. Methods: Retrospective chart review of all cases of CRS-HIPEC in children in our institution, examining diagnosis, preoperative management, operative management, postoperative treatment, short term outcome including length of stay and complications, and long term outcome including survival and recurrence of disease. Results: 9 children underwent CRS-HIPEC over 48 months. The mean age of the patients was 8 years. Tumors were: rhabdomyosarcoma (RMS), mesothelioma, Sertoli–Leydig, desmoplastic small round cell tumor, colon carcinoma and Wilms' tumor. Most patients received intraperitoneal cisplatin. Short term outcome was very good with median length of hospital stay of 13 days and low rate of complications. Seven patients were alive at last follow up. Five patients developed a recurrent disease. Recurrence was intraabdominal in two of these patients. Conclusions: CRS-HIPEC for children with disseminated intraabdominal malignancies performed in a dedicated institution and with guidance by a leading international center can be performed safely. Type of study: Treatment study.
AB - Purpose: Our purpose was to present our institutional experience with performing complete cytoreduction surgery and heated intraoperative chemotherapy (CRS-HIPEC) for children with disseminated intraabdominal malignancies, guided by a leading international center performing CRS-HIPEC in children. Methods: Retrospective chart review of all cases of CRS-HIPEC in children in our institution, examining diagnosis, preoperative management, operative management, postoperative treatment, short term outcome including length of stay and complications, and long term outcome including survival and recurrence of disease. Results: 9 children underwent CRS-HIPEC over 48 months. The mean age of the patients was 8 years. Tumors were: rhabdomyosarcoma (RMS), mesothelioma, Sertoli–Leydig, desmoplastic small round cell tumor, colon carcinoma and Wilms' tumor. Most patients received intraperitoneal cisplatin. Short term outcome was very good with median length of hospital stay of 13 days and low rate of complications. Seven patients were alive at last follow up. Five patients developed a recurrent disease. Recurrence was intraabdominal in two of these patients. Conclusions: CRS-HIPEC for children with disseminated intraabdominal malignancies performed in a dedicated institution and with guidance by a leading international center can be performed safely. Type of study: Treatment study.
KW - Children
KW - Cytoreduction
KW - Heated intraperitoneal chemotherapy
KW - Intraabdominal dissemination
UR - http://www.scopus.com/inward/record.url?scp=85048952084&partnerID=8YFLogxK
U2 - 10.1016/j.jpedsurg.2017.09.014
DO - 10.1016/j.jpedsurg.2017.09.014
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C2 - 29070431
AN - SCOPUS:85048952084
SN - 0022-3468
VL - 53
SP - 1381
EP - 1386
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
IS - 7
ER -