Cytoplasmic inclusions and X-ray microprobe analysis in a case of prolymphocytic leukemia

M. Djaldetti*, A. Eisbruch, J. Perek, J. Hart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A patient with prolymphocytic leukemia is described. The peripheral blood and bone-marrow cells contained nuclear pockets, bridges, and appendices, as well as cytoplasmic inclusions that were not membrane bound or connected with the endoplasmic reticulum. X-ray microanalysis of the cells showed them to contain large amounts of phosphorus, sulfur, chlorine, and calcium, as well as a smaller amount of sodium and magnesium in comparison with control lymphocytes. When compared with lymphocytes of a patient with chronic lymphocytic leukemia (CLL), the patient's cells showed higher amounts of magnesium, sulfur, and chlorine, while the sodium content was decreased. The usefulness of electron microscopy and X-ray microanalysis in the diagnosis of this type of leukemia is discussed.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalJournal of Cancer Research and Clinical Oncology
Issue number3
StatePublished - Oct 1984


  • Chronic lymphocytic leukemia
  • Cytoplasmic inclusions
  • Electron microscopy
  • Prolymphocytic leukemia
  • X-ray microanalysis


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