Cytomegalovirus retinitis in HIV-negative patients – associated conditions, clinical presentation, diagnostic methods and treatment strategy

Yinon Shapira, Michael Mimouni, Vicktoria Vishnevskia-Dai

Research output: Contribution to journalReview articlepeer-review

Abstract

In recent years, numerous reports have tied cytomegalovirus retinitis (CMVR) with multiple systemic conditions in the absence of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). These range from reports in apparently healthy individuals, through conditions rendering limited immune dysfunction such as advanced age and diabetes mellitus, and finally severe immune dysfunction such as in haematological and rheumatological conditions. Reports are also emerging, suggesting that induced local ocular immunosuppression is a risk factor for CMVR. We herein present a comprehensive collection of the accumulated findings regarding CMVR in non-HIV patients. We summarize the spectrum of underlying morbidity that has been associated with CMVR, its clinical presentation, diagnostic methods and treatment choice in the attempt to suggest the optimal treatment strategy in this complicated and diverse patient population which is still currently lacking a consensus.

Original languageEnglish
Pages (from-to)e761-e767
JournalActa Ophthalmologica
Volume96
Issue number7
DOIs
StatePublished - Nov 2018

Keywords

  • cytomegalovirus retinitis
  • healthy
  • HIV negative
  • intravitreal injection
  • paediatric
  • treatment

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