Cytomegalovirus infection in simultaneous pancreas-kidney transplantation

J. Malaise*, M. J. Ricart, A. Moreno, M. Crespo, L. Fernández-Cruz, D. Van Ophem, J. P. Squifflet, W. O. Bechstein, A. Kahl, J. Langrehr, I. Uhl, A. Engelking, P. Neuhaus, M. Stangl, W. D. Illner, A. Tarabichi, H. Schneeberger, Arbogast, W. Land, C. DieterleR. Landgraf, P. Boucek, M. Adamec, T. Havrdova, R. Koznarova, F. Saudek, W. Steurer, A. Königsrainer, R. Margreiter, Mark, L. Fernandez-Cruz, R. Nakache, R. Caldara, A. Secchi, B. Maes, D. Kuypers, W. Coosemans, P. Evenepoel, Th Messiaen, J. Pirenne, Y. Vanrenterghem, J. Sandberg, G. Tyden, M. Mourad, T. Berney, P. Majno, C. Toso, L. Bühler, G. Mentha, N. De Carpentry, S. Demuylder-Mischler, P. Morel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. In this open-label multicenter study, 205 simultaneous pancreas-kidney (SPK) transplant recipients between 1998 and 2000 were randomly assigned to tacrolimus or cyclosporine-microemulsion (ME). All patients received concomitant rATG induction therapy, mycophenolate mofetil and short-term corticosteroids. We report the 3-year data related to the occurrence, severity and effect of cytomegalovirus (CMV) infections. The type of CMV prophylaxis and treatment was at the discretion of the investigator. Results. The overall incidence of CMV infection was 34% with no difference in incidence between the tacrolimus and cyclosporine-ME treatment arms. Statistically significant fewer CMV infections occurred among patients who received ganciclovir (22%) than those who did not receive prophylaxis (42%; P = .0075) or were treated with acyclovir (43%; P = .0066). The CMV infection rate according to donor recipient CMV serological status was: D-/R- group 11%, which was lower than the D-/R+ group at 40% (P = .0035), the D+/R+ group at 37% (P = .0024), or the D+/R- group at 52% (P = .00001). Among the last three groups, the infection rate was lower in patients on ganciclovir than those with no prophylaxis or on acyclovir (22% vs 64%; P = .00001). The incidence of acute rejection episodes was higher among patients without ganciclovir prophylaxis. No difference was observed in actuarial patient, kidney, or pancreas survival rates between patients with versus without infection. Conclusions. Ganciclovir prophylaxis effectively prevented CMV infection in SPK transplant recipients, especially in higher risk groups. An effect of CMV prophylaxis on the incidence of rejection is possible.

Original languageEnglish
Pages (from-to)2848-2850
Number of pages3
JournalTransplantation Proceedings
Volume37
Issue number6
DOIs
StatePublished - 2005

Fingerprint

Dive into the research topics of 'Cytomegalovirus infection in simultaneous pancreas-kidney transplantation'. Together they form a unique fingerprint.

Cite this