Cytomegalovirus Infection in Pregnancy

Yoav Yinon, Dan Farine, Mark H. Yudin, Robert Gagnon, Lynda Hudon, Melanie Basso, Hayley Bos, Marie France Delisle, Dan Farine, Savas Menticoglou, William Mundle, Annie Ouellet, Tracy Pressey, Anne Roggensack, Mark H. Yudin, Marc Boucher, Eliana Castillo, Andrée Gruslin, Deborah M. Money, Kellie MurphyGina Ogilvie, Caroline Paquet, Nancy Van Eyk, Julie van Schalkwyk

Research output: Contribution to journalArticlepeer-review


Objectives: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. Outcomes: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment. These guidelines provide a framework for diagnosis and management of suspected CMV infections. Evidence: Medline was searched for articles published in English from 1966 to 2009, using appropriate controlled vocabulary (congenital CMV infection) and key words (intrauterine growth restriction, microcephaly). Results were restricted to systematic reviews, randomized controlled trials/controlled clinical trials, and observational studies. Searches were updated on a regular basis and incorporated into the guideline. Grey (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies.

Original languageEnglish
Pages (from-to)348-354
Number of pages7
JournalJournal of Obstetrics and Gynaecology Canada
Issue number4
StatePublished - 2010


  • CMV
  • Congenital infection
  • Cytomegalovirus
  • IUGR
  • Intrauterine growth restriction
  • Microcephaly
  • Prenatal diagnosis


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