Cytokine secretion and markers of inflammation in relation to acidosis among chronic hemodialysis patients

Yaacov Ori, Michael Bergman, Hanna Bessler, Boris Zingerman, Rachel S. Levy-Drummer, Uzi Gafter, Hertzel Salman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background: Various cytokines are increased in hemodialysis (HD) patients, and are considered prognostic markers. Metabolic acidosis is common among chronic HD patients and is associated with survival. The relationship between acidosis and cytokines in HD patients has not been fully explored. The study aim was to measure pro- and anti-inflammatory cytokines in HD patients, with relation to bicarbonate levels. Methods: Forty-seven stable HD patients were included (male/female 28/19, mean age 70.4 ± 14.5 years). Blood tests were taken before a midweek dialysis session. Cytokine secretion from peripheral blood mononuclear cells was measured. Results: Acidosis versus no acidosis (serum HCO3- 21.5 ± 0.2 vs. 24.9 ± 0.3 mEq/l, p < 0.001) was associated with decreased secretion of the anti-inflammatory interleukin-10 (IL-10, 1.16 ± 0.11 vs. 1.71 ± 0.20 ng/ml, p = 0.023). Patients with acidosis had higher parathyroid hormone (PTH), calcium-phosphate product, protein intake and transferrin. Higher IL-10 was associated with increased IL-6 secretion, higher bicarbonate, younger age and lower PTH. Conclusions: In stable chronic HD patients, a possible direct relation exists between metabolic acidosis and IL-10.

Original languageEnglish
Pages (from-to)181-186
Number of pages6
JournalBlood Purification
Volume35
Issue number1-3
DOIs
StatePublished - 2013

Keywords

  • Acidosis
  • Cytokines
  • Hemodialysis
  • Interleukin-10

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