Cytokine-chemokine and apoptotic signatures in patients with hepatitis C

Manuela G. Neuman*, Jean Pierre Benhamou, Patrick Marcellin, Dominique Valla, Izabella M. Malkiewicz, Gad G. Katz, Cristhian Trepo, Marc Bourliere, Ross G. Cameron, Lawrence Cohen, Mary Morgan, Hemda Schmilovitz-Weiss, Ziv Ben-Ari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cytokines and chemokines are proteins that play a critical role in the regulation of immunity and inflammation in patients with chronic Hepatitis C. The aim of our study was to correlate serum cytokines, chemokines and apoptosis in non-treated chronic hepatitis C patients with various degrees of inflammation and fibrosis. We studied 778 patients: 59 had low Knodell fibrosis score and low Knodell histological activity index; 372 had mild fibrosis and low histological activity index; 270 had moderate fibrosis and moderate histological activity index; and, 77 had high fibrosis and high histological activity index on their biopsy. Serum cytokines, chemokines and apoptosis were measured by enzyme-linked-immunosorbent-assay. Multivariate analysis was employed for statistical purposes. A positive correlation was seen between the degree of inflammation and tumor necrosis factor-alpha (TNF-α) levels (r=0.92) in non-cirrhotic patients and between interleukin 2 in all patients (r=0.85). Interleukin-8 increased significantly at higher histological activity indices and continued to increase in patients with cirrhosis. Transforming growth factor-beta (TGF-β) levels increased significantly with the severity of fibrosis, but decreased in cirrhotics. In conclusion, cytokines, chemokines and apoptosis levels reflect the progression of inflammation and fibrosis in hepatitis C infected patients, but their signatures differ.

Original languageEnglish
Pages (from-to)126-136
Number of pages11
JournalTranslational Research
Issue number3
StatePublished - Mar 2007
Externally publishedYes


FundersFunder number
Institute of Infection and Immunity of the Canadian Institutes of Health Research
Sackler Faculty of Medicine
National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism
Tel Aviv University


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