TY - JOUR
T1 - Cytogenetic analysis of three variants of clival chordoma
AU - Gil, Ziv
AU - Fliss, Dan M.
AU - Voskoboinik, Nadia
AU - Leider-Trejo, Leonor
AU - Spektor, Sergey
AU - Yaron, Yuval
AU - Orr-Urtreger, Avi
N1 - Funding Information:
We thank Esther Eshkol for her editorial assistance. This work was supported by a grant from the Israel Cancer Association to Z.G. and A.O-U.
PY - 2004/10/15
Y1 - 2004/10/15
N2 - Chordoma is an uncommon malignant neoplasm derived from remnants of the embryonal notochord. The tumor arises in the sacrococcygeal region in most cases. Cytogenetic information on clival chordomas is scarce due to the low incidence of these tumors. In this study, we applied the G-banding and spectral karyotyping techniques to compare the karyotypes of three variants of clival chordoma: conventional, chondroid, and dedifferentiated. We describe a normal karyotype of a chondroid chordoma and a complex karyotype of a conventional chordoma involving chromosomes 1, 2, 3, 5, 8, 9, 11, 15, 19, 20, and X. The cytogenetic analysis of the dedifferentiated chordoma showed a polyploid complex karyotype of 71-123 chromosomes with double minutes that originated from chromosome 17.
AB - Chordoma is an uncommon malignant neoplasm derived from remnants of the embryonal notochord. The tumor arises in the sacrococcygeal region in most cases. Cytogenetic information on clival chordomas is scarce due to the low incidence of these tumors. In this study, we applied the G-banding and spectral karyotyping techniques to compare the karyotypes of three variants of clival chordoma: conventional, chondroid, and dedifferentiated. We describe a normal karyotype of a chondroid chordoma and a complex karyotype of a conventional chordoma involving chromosomes 1, 2, 3, 5, 8, 9, 11, 15, 19, 20, and X. The cytogenetic analysis of the dedifferentiated chordoma showed a polyploid complex karyotype of 71-123 chromosomes with double minutes that originated from chromosome 17.
UR - http://www.scopus.com/inward/record.url?scp=5144235134&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2004.01.031
DO - 10.1016/j.cancergencyto.2004.01.031
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C2 - 15474147
AN - SCOPUS:5144235134
SN - 0165-4608
VL - 154
SP - 124
EP - 130
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -