Cytochrome c: A Thermodynamic Study of Relationships among Oxidation State, Ion‐Binding and Structural Parameters: 2. Ion‐Binding Linked to Oxidation State

Rimona Margalit*, Abel SCHEJTER

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The specific binding of anions to oxidized horse‐heart cytochrome c has been studied by two methods: measuring the effect of ion concentration on the redox potential, and directly by gel nitration. The anions investigated were: chloride, phosphate, ADP and sulfanilate. The binding constants estimated are in the range of 1–10 mM−1, and the number of sites per protein molecule are 1 to 2. The specificity of anion binding to the oxidized protein is demonstrated.

Original languageEnglish
Pages (from-to)500-505
Number of pages6
JournalEuropean Journal of Biochemistry
Volume32
Issue number3
DOIs
StatePublished - Feb 1973

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