Cystic fibrosis transmembrane conductance regulator ion channel function testing in recurrent acute pancreatitis

Idit Segal, Yasmin Yaakov, Samuel N. Adler, Hannah Blau, Efrat Broide, Moshe Santo, Yaakov Yahav, Aharon Klar, Aaron Lerner, Micha Aviram, Ian Ellis, Roger Mountford, Eyal Shteyer, Eitan Kerem, Michael Wilschanski

Research output: Contribution to journalArticlepeer-review

Abstract

Goals: To understand the relationship between acute recurrent pancreatitis and cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Background: An emerging number of patients present with a nonclassic phenotype of cystic fibrosis (CF) with partial features or single-organ disease only. The association between the phenotype of recurrent pancreatitis CFTR dysfunction is unclear. Methods: Patients with idiopathic recurrent pancreatitis were referred for electrophysiologic investigation. Results: Thirty-three patients (18 males) aged 20±12 years with recurrent pancreatitis were studied. Three patients had mild asthma and 1 patient had mild ulcerative colitis. There was no family history of CF. All patients had normal imaging of the pancreatic duct by endoscopic retrograde cholangiopancreatography or magnetic resonance cholangiopancreatography. No patient was pancreatic insufficient. Mean sweat chloride values were 41±14 meq/L (range: 18 to 64). Nasal potential difference (NPD) measurement was pathologic in 7 patients. Mean basal potential difference in these 7 patients was -33±13 mV and there was an abnormal response to chloride-free and isoproterenol solutions. There was no difference in sweat chloride concentration between the 2 groups. Mutation analysis revealed W1282X/5T, D1152H/5T, and W1282X/- in 3 patients with abnormal NPD and 1 W1282X allele was found in 1 patient with normal NPD. Conclusions: In this series, 21% of patients with recurrent pancreatitis have abnormalities of CFTR function. Patients presenting with recurrent, "idiopathic" pancreatitis require CFTR function testing.

Original languageEnglish
Pages (from-to)810-814
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume42
Issue number7
DOIs
StatePublished - Aug 2008
Externally publishedYes

Keywords

  • Cystic fibrosis
  • Nasal potential difference
  • Recurrent pancreatitis

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