TY - JOUR
T1 - Cyproheptadine treatment in neuroleptic-induced akathisia
AU - Weiss, D.
AU - Aizenberg, D.
AU - Hermesh, H.
AU - Zemishlany, Z.
AU - Munitz, H.
AU - Radwan, M.
AU - Weizman, A.
PY - 1995
Y1 - 1995
N2 - Background. Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic induced akathisia.Method. In an open clinical trial 17 neuroleptic treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. Results. All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. Conclusions. Cyproheptadine may be useful in neuroleptic-induced akethisia.
AB - Background. Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic induced akathisia.Method. In an open clinical trial 17 neuroleptic treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. Results. All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. Conclusions. Cyproheptadine may be useful in neuroleptic-induced akethisia.
UR - http://www.scopus.com/inward/record.url?scp=0029555371&partnerID=8YFLogxK
U2 - 10.1192/bjp.167.4.483
DO - 10.1192/bjp.167.4.483
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C2 - 8829717
AN - SCOPUS:0029555371
SN - 0007-1250
VL - 167
SP - 483
EP - 486
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - OCT.
ER -