CYP1A1 and CYP2D6 gene polymorphisms in Israeli jewish women with cervical cancer

Guy Gutman; Tova Morad; Ben Peleg; Chavah Peretz; Amiram Bar-Am; Tamar Safra; Dan Grisaru

doi:10.1111/IGC.0b013e3181b9fa5d

CYP1A1 and CYP2D6 gene polymorphisms in Israeli jewish women with cervical cancer

Guy Gutman, Tova Morad, Ben Peleg, Chavah Peretz, Amiram Bar-Am, Tamar Safra, Dan Grisaru^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reactionYbased method. Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003). Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.

Original language	English
Pages (from-to)	1300-1302
Number of pages	3
Journal	International Journal of Gynecological Cancer
Volume	19
Issue number	8
DOIs	https://doi.org/10.1111/IGC.0b013e3181b9fa5d
State	Published - Nov 2009

Keywords

CYP
Cervical cancer
Gene polymorphism

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/IGC.0b013e3181b9fa5d

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title = "CYP1A1 and CYP2D6 gene polymorphisms in Israeli jewish women with cervical cancer",

abstract = "Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reactionYbased method. Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003). Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.",

keywords = "CYP, Cervical cancer, Gene polymorphism",

author = "Guy Gutman and Tova Morad and Ben Peleg and Chavah Peretz and Amiram Bar-Am and Tamar Safra and Dan Grisaru",

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doi = "10.1111/IGC.0b013e3181b9fa5d",

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T1 - CYP1A1 and CYP2D6 gene polymorphisms in Israeli jewish women with cervical cancer

AU - Gutman, Guy

AU - Morad, Tova

AU - Peleg, Ben

AU - Peretz, Chavah

AU - Bar-Am, Amiram

AU - Safra, Tamar

AU - Grisaru, Dan

PY - 2009/11

Y1 - 2009/11

N2 - Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reactionYbased method. Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003). Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.

AB - Hypothesis: To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer. Methods: Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reactionYbased method. Results: The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003). Conclusion: CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population.

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KW - Cervical cancer

KW - Gene polymorphism

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CYP1A1 and CYP2D6 gene polymorphisms in Israeli jewish women with cervical cancer

Abstract

Keywords

UN SDGs

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