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Cyclosporine metabolic side effects: Association with the WNK4 system
Semyon Melnikov
,
Haim Mayan
*
, Shinichi Uchida
,
Eliezer J. Holtzman
,
Zvi Farfel
*
Corresponding author for this work
Clinical Departments
Laboratory of Biochemical Pharmacology
Tel Aviv University
Tokyo Medical and Dental University
Research output
:
Contribution to journal
›
Article
›
peer-review
55
Scopus citations
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Keyphrases
Blood Biochemistry
11%
Blood Pressure
11%
Cyclosporine
100%
GAPDH
11%
Hyperaldosteronism
11%
Hypercalciuria
33%
Hyperkalemia
66%
Hypertension
55%
Hypomagnesemia
22%
Immune-mediated Diseases
11%
Induced Hypertension
11%
K-Cl Cotransporter
44%
Kidney
22%
Metabolic Side Effects
100%
MRNA Level
11%
Phosphorylation
11%
Protein Content
55%
Protein Phosphorylation
11%
Salt Sensitivity
11%
Sprague-Dawley Rats
11%
Transplanted Patients
11%
WNK1
11%
WNK4
100%
Medicine and Dentistry
Blood Chemistry
14%
Blood Pressure
14%
Cyclosporine
100%
Diseases
14%
Hypercalciuria
42%
Hyperkalemia
85%
Hypomagnesemia
28%
Messenger RNA
28%
Protein Kinase WNK4
57%
Pseudohypoaldosteronism
14%
Serine/Threonine Protein Kinase WNK1
14%
Side Effect
100%
Sodium Chloride Cotransporter
57%
Table Salt
14%
Biochemistry, Genetics and Molecular Biology
Blood Pressure
11%
Ciclosporin
100%
Cotransporter
44%
Hypercalciuria
33%
Hyperkalemia
66%
Hypomagnesemia
22%
Messenger RNA
22%
Protein Content
55%
Pseudohypoaldosteronism
11%
Sprague Dawley Rat
11%
WNK1
11%
WNK4
100%