TY - JOUR
T1 - Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome
AU - Brazowski, Eli
AU - Misonzhnick-Bedny, Faina
AU - Rozen, Paul
N1 - Funding Information:
We are grateful to the Katzman Family Foundation for supporting the study; the Israel Cancer Society supports the Familial Cancer Clinic. We thank Ester Shabtai and Doron Comaneshter for statistical analyses, Ms. Sally Zimmerman for secretarial assistance, Dr. Gilad Gitstein for assistance in the performance of the study, and Dr. J. Jass, Montreal for his useful comments.
PY - 2004/11
Y1 - 2004/11
N2 - Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps' epithelium and stroma and comparison tissues (normal colonie mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3]) were quantified for COX-2 by: area of staining (0-3) x intensity (0-3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0 ± 3.0), stromal (6.9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P < 0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P < 0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.
AB - Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps' epithelium and stroma and comparison tissues (normal colonie mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3]) were quantified for COX-2 by: area of staining (0-3) x intensity (0-3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0 ± 3.0), stromal (6.9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P < 0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P < 0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.
KW - COX-2
KW - Chemoprevention
KW - Colorectal cancer
KW - Familial polyps
UR - http://www.scopus.com/inward/record.url?scp=13644262221&partnerID=8YFLogxK
U2 - 10.1007/s10620-004-9591-2
DO - 10.1007/s10620-004-9591-2
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C2 - 15628724
AN - SCOPUS:13644262221
VL - 49
SP - 1906
EP - 1911
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
SN - 0163-2116
IS - 11-12
ER -
