Cyclooxygenase-2 expression in the hereditary mixed polyposis syndrome

Eli Brazowski, Faina Misonzhnick-Bedny, Paul Rozen

Research output: Contribution to journalArticlepeer-review

Abstract

Hereditary mixed polyposis syndrome (HMPS), characterized by hyperplastic, juvenile, admixed, serrated adenomas and eventually colorectal cancer, is managed by repeated polypectomy and surgery. We determined if HMPS polyps express cyclooxygenase-2 (COX-2). Nineteen recent HMPS polyps, from five family members, were stained for COX-2. Polyps' epithelium and stroma and comparison tissues (normal colonie mucosa [9], sporadic juvenile polyps [18], colorectal cancers [3]) were quantified for COX-2 by: area of staining (0-3) x intensity (0-3). Epithelial, stromal, and total scores were evaluated in relationship to histology and dysplasia. HMPS polyps COX-2 mean epithelial (5.0 ± 3.0), stromal (6.9 ± 1.9), and total (11.8 ± 4.6) scores were significantly higher (P < 0.01) than sporadic juvenile polyps (0.6 ± 0.7, 3.1 ± 2.2, and 3.6 ± 2.2 respectively), while colorectal cancer scored 9, 9, and 18. There was a positive association (P < 0.01) among histology, degree of dysplasia, and COX-2 expression. COX-2 expression in HMPS polyps and its association with dysplasia suggest that chemoprevention might be a useful adjunct therapy.

Original languageEnglish
Pages (from-to)1906-1911
Number of pages6
JournalDigestive Diseases and Sciences
Volume49
Issue number11-12
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • COX-2
  • Chemoprevention
  • Colorectal cancer
  • Familial polyps

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