CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Jan Hendrik Niess; Stephan Brand; Xiubin Gu; Limor Landsman; Steffen Jung; Beth A. McCormick; Jatin M. Vyas; Marianne Boes; Hidde L. Ploegh; James G. Fox; Dan R. Littman; Hans Christian Reinecker

doi:10.1126/science.1102901

CX₃CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Jan Hendrik Niess, Stephan Brand, Xiubin Gu, Limor Landsman, Steffen Jung, Beth A. McCormick, Jatin M. Vyas, Marianne Boes, Hidde L. Ploegh, James G. Fox, Dan R. Littman, Hans Christian Reinecker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1357 Scopus citations

Abstract

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX₃CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX₃CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX ₃CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

Original language	English
Pages (from-to)	254-258
Number of pages	5
Journal	Science
Volume	307
Issue number	5707
DOIs	https://doi.org/10.1126/science.1102901
State	Published - 14 Jan 2005
Externally published	Yes

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	R01AI033856

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10.1126/science.1102901

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title = "CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance",

abstract = "Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX 3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.",

author = "Niess, {Jan Hendrik} and Stephan Brand and Xiubin Gu and Limor Landsman and Steffen Jung and McCormick, {Beth A.} and Vyas, {Jatin M.} and Marianne Boes and Ploegh, {Hidde L.} and Fox, {James G.} and Littman, {Dan R.} and Reinecker, {Hans Christian}",

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AU - Niess, Jan Hendrik

AU - Brand, Stephan

AU - Gu, Xiubin

AU - Landsman, Limor

AU - Jung, Steffen

AU - McCormick, Beth A.

AU - Vyas, Jatin M.

AU - Boes, Marianne

AU - Ploegh, Hidde L.

AU - Fox, James G.

AU - Littman, Dan R.

AU - Reinecker, Hans Christian

PY - 2005/1/14

Y1 - 2005/1/14

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AB - Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX 3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

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CX₃CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

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