CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Jan Hendrik Niess, Stephan Brand, Xiubin Gu, Limor Landsman, Steffen Jung, Beth A. McCormick, Jatin M. Vyas, Marianne Boes, Hidde L. Ploegh, James G. Fox, Dan R. Littman, Hans Christian Reinecker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX 3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
Issue number5707
StatePublished - 14 Jan 2005
Externally publishedYes


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