Cutting Edge: MHC class I-Ly49 interaction regulates neuronal function

Ofer Zohar, Yoram Reiter, Jack R. Bennink, Avital Lev, Sebastiano Cavallaro, Sabrina Paratore, Chaim G. Pick, Gary Brooker, Jonathan W. Yewdell

Research output: Contribution to journalArticlepeer-review


MHC class I molecules (MHC-I) have been implicated in nervous system development in the mouse. In this study we present evidence for the interaction of MHC-I with the NK cell receptor Ly49 in primary cortical neuronal cultures. We show that MHC-I and Ly49 are expressed on neuronal soma and axon surfaces, with Ly49 also present on dendrites. Anti-MHC-I Abs reduce synapsin-I expression and enhance neurite outgrowth and neuronal death. Conversely, anti-Ly49 mAbs increase synapsin-I expression, reduce neurite outgrowth, and promote neuron viability. Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain.

Original languageEnglish
Pages (from-to)6447-6451
Number of pages5
JournalJournal of Immunology
Issue number10
StatePublished - 2008


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