TY - JOUR
T1 - Cutting Edge
T2 - MHC class I-Ly49 interaction regulates neuronal function
AU - Zohar, Ofer
AU - Reiter, Yoram
AU - Bennink, Jack R.
AU - Lev, Avital
AU - Cavallaro, Sebastiano
AU - Paratore, Sabrina
AU - Pick, Chaim G.
AU - Brooker, Gary
AU - Yewdell, Jonathan W.
PY - 2008
Y1 - 2008
N2 - MHC class I molecules (MHC-I) have been implicated in nervous system development in the mouse. In this study we present evidence for the interaction of MHC-I with the NK cell receptor Ly49 in primary cortical neuronal cultures. We show that MHC-I and Ly49 are expressed on neuronal soma and axon surfaces, with Ly49 also present on dendrites. Anti-MHC-I Abs reduce synapsin-I expression and enhance neurite outgrowth and neuronal death. Conversely, anti-Ly49 mAbs increase synapsin-I expression, reduce neurite outgrowth, and promote neuron viability. Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain.
AB - MHC class I molecules (MHC-I) have been implicated in nervous system development in the mouse. In this study we present evidence for the interaction of MHC-I with the NK cell receptor Ly49 in primary cortical neuronal cultures. We show that MHC-I and Ly49 are expressed on neuronal soma and axon surfaces, with Ly49 also present on dendrites. Anti-MHC-I Abs reduce synapsin-I expression and enhance neurite outgrowth and neuronal death. Conversely, anti-Ly49 mAbs increase synapsin-I expression, reduce neurite outgrowth, and promote neuron viability. Because we show that Ly49 genes are selectively expressed in the adult brain, these findings suggest an unsuspected role for the MHC-I-Ly49 interaction in the development and function of the brain.
UR - http://www.scopus.com/inward/record.url?scp=45549097249&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.180.10.6447
DO - 10.4049/jimmunol.180.10.6447
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AN - SCOPUS:45549097249
SN - 0022-1767
VL - 180
SP - 6447
EP - 6451
JO - Journal of Immunology
JF - Journal of Immunology
IS - 10
ER -