TY - JOUR
T1 - Cutting edge
T2 - Anti-inflammatory properties of low levels of IFN-γ
AU - Flaishon, Liat
AU - Topilski, Ian
AU - Shoseyov, David
AU - Hershkoviz, Rami
AU - Fireman, Elizabeth
AU - Levo, Yoram
AU - Marmor, Sylvia
AU - Shachar, Idit
PY - 2002/4/15
Y1 - 2002/4/15
N2 - Activation of naive T and B cells occurs only within the context of organized lymphoid tissue. Thus, the continuous recirculation of mature lymphocytes is crucial for the development of primary immune response to foreign Ags. We have previously shown that low levels of IFN-γ inhibit homing of B cells to the secondary lymphoid organs. In this study, we demonstrate that similarly low doses of IFN-γ down-regulate integrin-mediated adhesion and migration of naive T and Th2 cells, and have a profound effect on the in vivo homing of naive T cells to the lymph nodes. Moreover, we show that these low doses of IFN-γ have anti-inflammatory effects in an in vivo asthma model. Thus, in contrast to the proinflammatory effects of IFN-γ at relatively high concentrations, low dose IFN-γ appears to exert global suppressory effects on T cell trafficking and may have clinical application as an anti-inflammatory agent.
AB - Activation of naive T and B cells occurs only within the context of organized lymphoid tissue. Thus, the continuous recirculation of mature lymphocytes is crucial for the development of primary immune response to foreign Ags. We have previously shown that low levels of IFN-γ inhibit homing of B cells to the secondary lymphoid organs. In this study, we demonstrate that similarly low doses of IFN-γ down-regulate integrin-mediated adhesion and migration of naive T and Th2 cells, and have a profound effect on the in vivo homing of naive T cells to the lymph nodes. Moreover, we show that these low doses of IFN-γ have anti-inflammatory effects in an in vivo asthma model. Thus, in contrast to the proinflammatory effects of IFN-γ at relatively high concentrations, low dose IFN-γ appears to exert global suppressory effects on T cell trafficking and may have clinical application as an anti-inflammatory agent.
UR - http://www.scopus.com/inward/record.url?scp=0037090282&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.168.8.3707
DO - 10.4049/jimmunol.168.8.3707
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AN - SCOPUS:0037090282
SN - 0022-1767
VL - 168
SP - 3707
EP - 3711
JO - Journal of Immunology
JF - Journal of Immunology
IS - 8
ER -