Cutaneous chronic graft versus host disease following allogeneic haematopoietic stem cell transplantation in children: A retrospective study

Rony Shreberk-Hassidim, Michal Neumark, Shoshana Greenberger, Gal Goldstein, Ayal Hassidim, Yuval Dukler, Alexander Maly, Polina Stepensky, Vered Molho-Pessach

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic graft versus host disease (cGVHD) is a complication of allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to clinically characterize childhood cutaneous cGVHD. A retrospective study of children treated with HSCT at 2 tertiary medical centres in Israel between 2011 and 2014 was performed. A total of 112 children were included. Cutaneous cGVHD developed in 18% of subjects. Risk factors were older age, HSCT from peripheral blood and acute lymphoblastic leukaemia. The eruption was lichenoid in 90% of subjects, of whom one-third progressed to sclerosis. Topical treatments were usually sufficient in localized disease. Widespread eruption necessitated phototherapy, extracorporeal photopheresis and/or systemic immunosuppressants. Patients presenting with palmoplantar keratoderma, developed sclerosis. To the best of our knowledge, this is the first study describing childhood cutaneous cGV-HD. Lichenoid eruption is the most common cutaneous pattern of cGVHD in children. Sclerotic changes may be associated with prior keratoderma. cGVHD poses a therapeutic challenge and better treatments should be sought.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalActa Dermato-Venereologica
Volume98
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • Allogeneic haematopoietic cell transplantation
  • Children
  • Chronic cutaneous graft versus host disease
  • Graft versus host disease
  • Lichenoid
  • Sclerotic

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