Customizing MRI-Compatible Multifunctional Neural Interfaces through Fiber Drawing

Marc Joseph Antonini, Atharva Sahasrabudhe, Anthony Tabet, Miriam Schwalm, Dekel Rosenfeld, Indie Garwood, Jimin Park, Gabriel Loke, Tural Khudiyev, Mehmet Kanik, Nathan Corbin, Andres Canales, Alan Jasanoff, Yoel Fink, Polina Anikeeva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Fiber drawing enables scalable fabrication of multifunctional flexible fibers that integrate electrical, optical, and microfluidic modalities to record and modulate neural activity. Constraints on thermomechanical properties of materials, however, have prevented integrated drawing of metal electrodes with low-loss polymer waveguides for concurrent electrical recording and optical neuromodulation. Here, two fabrication approaches are introduced: 1) an iterative thermal drawing with a soft, low melting temperature (Tm) metal indium, and 2) a metal convergence drawing with traditionally non-drawable high Tm metal tungsten. Both approaches deliver multifunctional flexible neural interfaces with low-impedance metallic electrodes and low-loss waveguides, capable of recording optically-evoked and spontaneous neural activity in mice over several weeks. These fibers are coupled with a light-weight mechanical microdrive (1 g) that enables depth-specific interrogation of neural circuits in mice following chronic implantation. Finally, the compatibility of these fibers with magnetic resonance imaging is demonstrated and they are applied to visualize the delivery of chemical payloads through the integrated channels in real time. Together, these advances expand the domains of application of the fiber-based neural probes in neuroscience and neuroengineering.

Original languageEnglish
Article number2104857
JournalAdvanced Functional Materials
Volume31
Issue number43
DOIs
StatePublished - 20 Oct 2021
Externally publishedYes

Funding

FundersFunder number
Center for Materials Science and EngineeringDMR‐1419807
Institute for Soldier NanotechnologiesW911NF‐13‐D‐000, NA18OAR4170105
Lore Harp McGovern Fellowship
McGovern
McGovern Institute for Brain Research
NSF Center for NeurotechnologyEEC-1028725
National Science Foundation
National Institutes of HealthEEC‐1028725, U01 NS107712
U.S. Department of DefenseSA21‐03
National Institute of Neurological Disorders and StrokeR01‐NS115025‐01A1
Army Research Office
Defense Threat Reduction Agency
Army Research Laboratory
Massachusetts Institute of Technology
Kwanjeong Educational Foundation1745032

    Keywords

    • fibers
    • magnetic resonance imaging
    • microdrives
    • multifunctional neural probes
    • thermal drawing

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