Curcumin alone and in combination for prevention of colorectal cancer

Nataly Shemesh, Nadir Arber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Colorectal cancer (CRC) is a major health concern. It is the third most common type of cancer and cause of death by cancer. Chemoprevention is a promising approach for reducing morbidity and mortality from CRC. The search for a chemoprevention agent with mild side effects has led to particular interest in curcumin. In-vitro and in-vivo studies indicate that curcumin can interfere with multiple cell signaling pathways involved in carcinogenesis, including inhibition of cell cycle progression, induction of apoptosis, slowing of proliferation, and reduction of angiogenesis, invasion, and metastasis formation. Curcumin is also a very potent anti-inflammatory agent and anti-oxidative agent. Curcumin has no adverse effects on normal cells, making it a very promising chemopreventive agent.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalCurrent Colorectal Cancer Reports
Volume10
Issue number1
DOIs
StatePublished - Mar 2014

Keywords

  • Celecoxib
  • Chemoprevention
  • Colorectal cancer
  • Coltect
  • Curcumin

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