Cumulative pregnancy rate following in-vitro fertilization: The significance of age and infertility aetiology

J. Dor, D. S. Seidman, I. Ben-Shlomo, D. Levran, Z. Ben-Rafael, S. Mashiach

Research output: Contribution to journalArticlepeer-review

Abstract

During the years 1984-1992, 951 couples completed 2252 in-vitro fertilization (IVF) treatment cycles at the In-Vitro Fertilization Unit of The Chaim Sheba Medical Centre. This study was conducted to evaluate the success of IVF using the cumulative pregnancy rate (CPR), with special emphasis on the optimal number of treatment cycles, the age of the patients and female infertility factors. It was found that the CPR showed a constant rise during the six initial IVF treatments (56% CPR), and plateaued in the subsequent three cycles (63% CPR), Various female infertility factors did not influence this rate. Women ≥40 years of age have a significantly lower CPR, Thus, it was concluded that the CPR in IVF declined after the sixth initial treatment cycle, and in women ≥40 years of age. The infertility factor did not significantly influence CPR.

Original languageEnglish
Pages (from-to)425-428
Number of pages4
JournalHuman Reproduction
Volume11
Issue number2
DOIs
StatePublished - Feb 1996

Keywords

  • Cumulative pregnancy rates
  • Fertility by age
  • IVF
  • Infertility factor

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