Cumulative live birth rate following in vitro fertilization: Study of 5310 cycles

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Most previous studies that calculated cumulative delivery rates following in vitro fertilization (IVF) treatments were limited in the number of cycles and the implementation of intracytoplasmic sperm injection (ICSI). Therefore, we assessed the yield of high-order consecutive IVF treatments (up to 14 consecutive cycles) with and without ICSI. Data from IVF cycles performed in a single center were retrieved from a computerized database. A total of 5310 cycles among 1928 patients were evaluated and cumulative delivery rates until the first delivery were calculated using life-table analyses. There were 1126 pregnancies resulting in 689 live births. Cumulative delivery rates reached 87% following 14 consecutive cycles. Cumulative delivery rates were higher following ICSI compared with cycles without (92.7% vs. 85.4%). In conclusion, each treatment cycle increased the cumulative delivery rate, resulting in a rate of 87% after 14 consecutive cycles. The introduction of ICSI resulted in the highest cumulative rates.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalGynecological Endocrinology
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Cumulative delivery rate
  • In vitro fertilization
  • Intracytoplasmic sperm injection


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