CSF renin activity in hypertensive and normotensive patients

J. Vardi, E. Kisch, N. Bornstein, A. Alguetti, S. Flechter, I. Regev

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Abstract

CSF samples of hypertensive and normotensive matched groups were assayed and compared for renin activity (RA). The measurements yield low values of RA in both groups without significant difference between them. There was no correlation between the CSF level of RA of each patient and his own concomitant plasma renin activity (PRA). Although the presence of RA in the CSF was confirmed in this study, no direct correlation seems to exist between its values and the elevated blood pressure; therefore, the pathophysiological significance of the renin-angiotensin system in the CSF and its relation to centrally generated by hypertension remains questionable.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalSwiss Archives of Neurology, Psychiatry and Psychotherapy
Volume129
Issue number2
StatePublished - 1981

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