CSF plasmablasts differentiate MS from other neurologic disorders

I. Kister*, I. Lotan, A. Wallach, T. Bacon, G. Cutter, A. Arbini

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


Multiparametric flow cytometry (FC) of CSF allows one to easily estimate the percentage of lymphocyte subpopulations in CSF. We hypothesized that an increased ratio of B-lineage cells in CSF of MS patients, as assessed with FC, could be useful for diagnostics. We analyzed CSF of 137 patients (70 MS, 24 infectious/autoimmune neurologic disorders (INDs), and 43 non-infectious/autoimmune neurologic disorders (NINDs)), and showed that CSF plasmablasts of >0.1% had a sensitivity of 40% for MS and specificity of 92% when comparing MS and IND, while plasmablasts of >0.25% had sensitivity of 36%, and 100% specificity.

Original languageEnglish
Article number102719
JournalMultiple Sclerosis and Related Disorders
StatePublished - Feb 2021


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