CSF homovanillic acid in schizotypal personality disorder

Larry J. Siever*, Farooq Amin, Emil F. Coccaro, Robert Trestman, Jeremy Silverman, Thomas B. Horvath, Theresa R. Mahon, Peter Knott, Larry Altstiel, Michael Davidson, Kenneth L. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalAmerican Journal of Psychiatry
Volume150
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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