TY - JOUR
T1 - Cryptococcosis as a cause of nephrotic syndrome? A case report and review of the literature
AU - Cohen, Regev
AU - Babushkin, Frida
AU - Shapiro, Maurice
AU - Ben-Ami, Ronen
AU - Finn, Talya
N1 - Publisher Copyright:
© 2018 The Authors
PY - 2018/1/1
Y1 - 2018/1/1
N2 - We present a case of a 74 years old male with cutaneous cryptococcosis of the right forearm. Cryptococcus neoformans var. neoformans was cultivated from the skin and from the bloodstream. He was diagnosed with nephrotic syndrome (focal segmental glomerulosclerosis) 21 months prior to admission, which was steroid-dependent. He was treated with prednisone and cyclosporine A. Concurrently with his renal disease he was also diagnosed as having disseminated severe tinea mannum, tinea corporis and tinea cruris; onychomycosis, skin eczema and psoriasis. After a prolonged course of anti-fungal therapy, his skin lesions as well as his nephrotic syndrome recovered completely. Follow up after 7 months without any anti-fungal or immunosuppression showed no skin or renal recurrence. We assume that the renal disease was related to the pre-existing cutaneous cryptococcosis, aggravated by immunosuppression, and discuss the close association between cutaneous cryptococcosis and nephrotic syndrome, as well as similar case reports in the literature.
AB - We present a case of a 74 years old male with cutaneous cryptococcosis of the right forearm. Cryptococcus neoformans var. neoformans was cultivated from the skin and from the bloodstream. He was diagnosed with nephrotic syndrome (focal segmental glomerulosclerosis) 21 months prior to admission, which was steroid-dependent. He was treated with prednisone and cyclosporine A. Concurrently with his renal disease he was also diagnosed as having disseminated severe tinea mannum, tinea corporis and tinea cruris; onychomycosis, skin eczema and psoriasis. After a prolonged course of anti-fungal therapy, his skin lesions as well as his nephrotic syndrome recovered completely. Follow up after 7 months without any anti-fungal or immunosuppression showed no skin or renal recurrence. We assume that the renal disease was related to the pre-existing cutaneous cryptococcosis, aggravated by immunosuppression, and discuss the close association between cutaneous cryptococcosis and nephrotic syndrome, as well as similar case reports in the literature.
KW - Cryptococcemia
KW - Cryptococcus neoformans
KW - Focal segmental glomerulosclerosis
KW - Misdiagnosis
KW - Nephrotic syndrome
KW - Primary cutaneous cryptococcosis
KW - Psoriasis
KW - Tinea
UR - http://www.scopus.com/inward/record.url?scp=85047146511&partnerID=8YFLogxK
U2 - 10.1016/j.idcr.2018.05.004
DO - 10.1016/j.idcr.2018.05.004
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AN - SCOPUS:85047146511
SN - 2214-2509
VL - 12
SP - 142
EP - 148
JO - IDCases
JF - IDCases
ER -