Cryohemostasis of uncontrolled hemorrhage from liver injury

Doron Kopelman, Yoram Klein, Asaph Zaretsky, Ofer Ben-Izhak*, Moshe Michaelson, Moshe Hashmonai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Uncontrolled hemorrhage is the primary cause of death in both blunt and penetrating liver trauma. Cryohemostasis was attempted in the past for elective liver surgery but did not gain popularity. During past decades, cryoequipment was refined and successfully used for tumor ablation. The purpose of the present study was to assess the efficacy of cryosurgery as a potential adjuvant hemostatic technique in the treatment of grades III-IV liver injuries. A standard liver crush-evulsion injury was created in pigs. In the control group, the liver was left to bleed freely. In the experimental group, the severed liver surface was immediately frozen to -160°C for 10 min, spontaneously thawed, and left to bleed thereafter. Blood pressure, pulse rate, urine output, and serum lactate were monitored. The total blood loss was measured 180 min after liver injury was inflicted. The volume of frozen liver parenchyma was measured. For further laboratory evaluation, three additional experimental animals were not sacrificed and recovered. Cryohemostasis significantly reduced blood loss and substantially attenuated hemorrhagic shock. The frozen liver parenchyma underwent necrosis but did not jeopardize survival. Cryosurgery may be an efficient adjuvant technique in the early control of hemorrhage in grades III-IV liver injury. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalCryobiology
Volume40
Issue number3
DOIs
StatePublished - May 2000
Externally publishedYes

Keywords

  • Cryosurgery
  • Hemorrhage
  • Liver trauma

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