CRP velocity and short-term mortality in ST segment elevation myocardial infarction

Assi Milwidsky, Tomer Ziv-Baran, Sevan Letourneau-Shesaf, Gad Keren, Philippe Taieb, Shlomo Berliner, Yacov Shacham

Research output: Contribution to journalArticlepeer-review

Abstract

Context: There is a known association between C-reactive protein (CRP) levels and adverse outcomes in patients presenting with ST-elevation myocardial infarction (STEMI). The optimal time frame to measure CRP for risk stratification is not known. Objective: The aim of the current study was to evaluate the relation between the change in CRP velocity (CRPv) and 30-d mortality among STEMI patients. Material and methods: We included consecutive patients with a diagnosis of STEMI who presented to Tel-Aviv Medical Center between 2008 and 2014 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission. CRPv was defined as the change in wr-CRP concentration (mg/l) divided by the change in time (in hours) between the two measurements. Results: The study population comprised of 492 patients, mean age was 62 ± 14, 80% were male. CRPv was significantly higher among patients who died within 30 d of admission (1.42 mg/l versus 0.18 mg/l, p < 0.001). In a multivariate regression model adjusted to multiple confounders, CRPv was independently associated with 30-d mortality (OR 1.39, 95% CI: 1.20–1.62, p < 0.001). Conclusion: CRPv might be an independent and rapidly measurable biomarker for short-term mortality in patients presenting with STEMI.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalBiomarkers
Volume22
Issue number3-4
DOIs
StatePublished - 19 May 2017

Keywords

  • C-reactive protein
  • CRP velocity
  • acute myocardial infarction
  • biomarkers
  • inflammation

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