@article{c541f89893134065a4f60a7211101bad,
title = "Cross Species Genomic Analysis Identifies a Mouse Model as Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma",
abstract = "Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-KrasG12D; Trp53Flox/Flox mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the LSL-KrasG12D; p53Flox/Flox mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.",
author = "Mito, {Jeffrey K.} and Riedel, {Richard F.} and Leslie Dodd and Guy Lahat and Lazar, {Alexander J.} and Dodd, {Rebecca D.} and Lars Stangenberg and Eward, {William C.} and Hornicek, {Francis J.} and Yoon, {Sam S.} and Brigman, {Brian E.} and Tyler Jacks and Dina Lev and Sayan Mukherjee and Kirsch, {David G.}",
year = "2009",
doi = "10.1371/journal.pone.0008075",
language = "אנגלית",
volume = "4",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",
}