Cross resistance to ciprofloxacin and other antimicrobial agents among clinical isolates of Acinetobacter calcoaceticus biovar anitratus

I. Shalit, M. Dan, R. Gutman, A. Gorea, S. A. Berger

Research output: Contribution to journalArticlepeer-review

Abstract

Using an agar dilution assay, for 66 of 104 (63.5%) clinical isolates of Acinetobacter calcoaceticus biovar anitratus, the MIC of ciprofloxacin was ≥ 1.0 μg/ml. Cross resistance was demonstrable to ciprofloxacin and gentamicin (P < 0.001), amikacin (P < 0.01), cefotaxime (P < 0.001), azlocillin (P < 0.001), ceftazidime (P < 0.001), trimethoprim-sulfamethoxazole (P < 0.001), and minocycline (P < 0.05). The mean MIC of ciprofloxacin for drug-susceptible isolates was consistently lower than that for resistant isolates; however, these differences were significant only for amikacin (P = 0.036).

Original languageEnglish
Pages (from-to)494-495
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

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