CRISPR adaptation in Escherichia coli subtype I-E system

Ruth Kiro, Moran G. Goren, Ido Yosef, Udi Qimron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The CRISPRs (clustered regularly interspaced short palindromic repeats) and their associated Cas (CRISPRassociated) proteins are a prokaryotic adaptive defence system against foreign nucleic acids. The CRISPR array comprises short repeats flanking short segments, Called 'spacers', which are derived from foreign nucleic acids. The process of spacer insertion into the CRISPR array is termed 'adaptation'. Adaptation allows the system to rapidly evolve against emerging threats. In the present article, we review the most recent studies on the adaptation process, and focus primarily on the subtype I-E CRISPR-Cas system of Escherichia coli.

Original languageEnglish
Pages (from-to)1412-1415
Number of pages4
JournalBiochemical Society Transactions
Issue number6
StatePublished - Dec 2013


  • Clustered regularly interspaced short palindromic repeats (CRISPR)
  • Defence mechanism
  • Escherichia coli
  • Phage-host interaction
  • Spacer acquisition
  • Subtype I-E system


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