Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch

Tal Dvir, Jonathan Leor, Smadar Cohen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Tissue engineering is an approach used to create a functional cardiac patch for the purpose of scar support after a myocardial infarct (MI). Cardiac cells, or cells of other sources, are seeded into scaffolds, which provide an artificial biomechanical support until the cells secrete extracellular matrix and regenerate into a functional tissue. In this chapter we describe the creative design of various cell microenvironments, which promote the development of a thick vascularized cardiac patch, ready to face the harsh conditions of the infarcted heart. Among these microenvironments are unique bioreactor systems that increase mass transfer through the developing cardiac tissue at the in vitro engineering stage and the use of various vascularization techniques, including the use of the body as a bioreactor to induce rapid vascularization prior to transplantation on the infarcted heart.

Original languageEnglish
Title of host publicationStudies in Mechanobiology, Tissue Engineering and Biomaterials
PublisherSpringer
Pages81-94
Number of pages14
DOIs
StatePublished - 2011

Publication series

NameStudies in Mechanobiology, Tissue Engineering and Biomaterials
Volume6
ISSN (Print)1868-2006
ISSN (Electronic)1868-2014

Keywords

  • Cardiac Tissue
  • Infarcted Heart
  • Microvascular Network
  • Perfusion Bioreactor
  • Vascular Endothelial Growth Factor

Fingerprint

Dive into the research topics of 'Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch'. Together they form a unique fingerprint.

Cite this