Creatine kinase levels in psychotic adolescents

T. Schechtman, I. Manor, D. Stein, H. Hermesen, H. Munitz, A. Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An increase in the levels of Creatine Kinase (CK) occurs in 10% of acute adult psychotic patients. This Ckemia (500-1000 IU; normal level up to 200 IU) terminates within a few days. It characterizes a specific group of psychotic patients, particularly males, tends to recur with subsequent hospitalizations, and not related to muscle destruction (no hemoglobinuria or myoglobinuria). Methods: The present study examined the rate and characteristics of Ckemia in psychotic adolescents (age 12-20) hospitalized at the Abarbanel Mental Health Center, Bat Yam. Exclusion criteria were evidence of injuries prior to the hospitalization, physical limitation, receiving depot neuroleptics in the previous month and administration of injections. Patients were diagnosed with psychosis according to the criteria of the DSM-IV, and all had BPRS levels above 40. Laboratory examinations, including CK, were taken on admission. Results: Of the 78 psychotic adolescents, 24% had evidence of Ckemia. Significantly more males demonstrated this disorder. CK levels were significantly correleted with levels of cholesterol (negative correlation), creatinine, glutamic oxaloacetic transaminase (SCOT), lactic dehydrogenase (LDH) (all positive correlations) and number of white blood cells. There was no evidence of muscle destruction in any of the patients. Conclusions: Ckemia may be more frequent in psychotic adolescents compared to adults. Its association with increased levels of other muscle enzymes (SGOT, LDH), relates this phenomenon to the acute psychotic state.

Original languageEnglish
Pages (from-to)320
Number of pages1
JournalIsrael Journal of Psychiatry and Related Sciences
Volume34
Issue number4
StatePublished - 1997
Externally publishedYes

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