Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study

Ellie G. Maghami, Simon G. Talbot, Snehal G. Patel, Bhuvanesh Singh, Ashok Polluri, Patrick G. Bridger, Giulio Cantu, Anthony D. Cheesman, Geraldo De Sa, Paul Donald, Luiz R.M. Dos Santos, Dan Fliss, Patrick Gullane, Ivo Janecka, Shin Etsu Kamata, Luiz P. Kowalski, Dennis H. Kraus, Paul A. Levine, Sultan Pradhan, Victor SchrammCarl Snyderman, William I. Wei, Jatin P. Shah*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome.

Original languageEnglish
Pages (from-to)1136-1143
Number of pages8
JournalHead and Neck
Issue number12
StatePublished - Dec 2007
Externally publishedYes


  • Basal cell carcinoma
  • Head and neck
  • International collaboration
  • Skin cancer
  • Skull base neoplasm
  • Skull base/craniofacial surgery
  • Squamous cell carcinoma
  • Treatment outcome


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