Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study

Ellie G. Maghami; Simon G. Talbot; Snehal G. Patel; Bhuvanesh Singh; Ashok Polluri; Patrick G. Bridger; Giulio Cantu; Anthony D. Cheesman; Geraldo De Sa; Paul Donald; Luiz R.M. Dos Santos; Dan Fliss; Patrick Gullane; Ivo Janecka; Shin Etsu Kamata; Luiz P. Kowalski; Dennis H. Kraus; Paul A. Levine; Sultan Pradhan; Victor Schramm; Carl Snyderman; William I. Wei; Jatin P. Shah

doi:10.1002/hed.20656

Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study

Ellie G. Maghami, Simon G. Talbot, Snehal G. Patel, Bhuvanesh Singh, Ashok Polluri, Patrick G. Bridger, Giulio Cantu, Anthony D. Cheesman, Geraldo De Sa, Paul Donald, Luiz R.M. Dos Santos, Dan Fliss, Patrick Gullane, Ivo Janecka, Shin Etsu Kamata, Luiz P. Kowalski, Dennis H. Kraus, Paul A. Levine, Sultan Pradhan, Victor SchrammCarl Snyderman, William I. Wei, Jatin P. Shah^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome.

Original language	English
Pages (from-to)	1136-1143
Number of pages	8
Journal	Head and Neck
Volume	29
Issue number	12
DOIs	https://doi.org/10.1002/hed.20656
State	Published - Dec 2007
Externally published	Yes

Keywords

Basal cell carcinoma
Head and neck
International collaboration
Skin cancer
Skull base neoplasm
Skull base/craniofacial surgery
Squamous cell carcinoma
Treatment outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.20656

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Maghami, E. G., Talbot, S. G., Patel, S. G., Singh, B., Polluri, A., Bridger, P. G., Cantu, G., Cheesman, A. D., De Sa, G., Donald, P., Dos Santos, L. R. M., Fliss, D., Gullane, P., Janecka, I., Kamata, S. E., Kowalski, L. P., Kraus, D. H., Levine, P. A., Pradhan, S., ... Shah, J. P. (2007). Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study. Head and Neck, 29(12), 1136-1143. https://doi.org/10.1002/hed.20656

@article{0e6a46e8775c4e1bb4ac0d02f2e306b4,

title = "Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study",

abstract = "Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome.",

keywords = "Basal cell carcinoma, Head and neck, International collaboration, Skin cancer, Skull base neoplasm, Skull base/craniofacial surgery, Squamous cell carcinoma, Treatment outcome",

author = "Maghami, {Ellie G.} and Talbot, {Simon G.} and Patel, {Snehal G.} and Bhuvanesh Singh and Ashok Polluri and Bridger, {Patrick G.} and Giulio Cantu and Cheesman, {Anthony D.} and {De Sa}, Geraldo and Paul Donald and {Dos Santos}, {Luiz R.M.} and Dan Fliss and Patrick Gullane and Ivo Janecka and Kamata, {Shin Etsu} and Kowalski, {Luiz P.} and Kraus, {Dennis H.} and Levine, {Paul A.} and Sultan Pradhan and Victor Schramm and Carl Snyderman and Wei, {William I.} and Shah, {Jatin P.}",

year = "2007",

month = dec,

doi = "10.1002/hed.20656",

language = "אנגלית",

volume = "29",

pages = "1136--1143",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons Inc.",

number = "12",

}

Maghami, EG, Talbot, SG, Patel, SG, Singh, B, Polluri, A, Bridger, PG, Cantu, G, Cheesman, AD, De Sa, G, Donald, P, Dos Santos, LRM, Fliss, D, Gullane, P, Janecka, I, Kamata, SE, Kowalski, LP, Kraus, DH, Levine, PA, Pradhan, S, Schramm, V, Snyderman, C, Wei, WI & Shah, JP 2007, 'Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study', Head and Neck, vol. 29, no. 12, pp. 1136-1143. https://doi.org/10.1002/hed.20656

TY - JOUR

T1 - Craniofacial surgery for nonmelanoma skin malignancy

T2 - Report of an international collaborative study

AU - Maghami, Ellie G.

AU - Talbot, Simon G.

AU - Patel, Snehal G.

AU - Singh, Bhuvanesh

AU - Polluri, Ashok

AU - Bridger, Patrick G.

AU - Cantu, Giulio

AU - Cheesman, Anthony D.

AU - De Sa, Geraldo

AU - Donald, Paul

AU - Dos Santos, Luiz R.M.

AU - Fliss, Dan

AU - Gullane, Patrick

AU - Janecka, Ivo

AU - Kamata, Shin Etsu

AU - Kowalski, Luiz P.

AU - Kraus, Dennis H.

AU - Levine, Paul A.

AU - Pradhan, Sultan

AU - Schramm, Victor

AU - Snyderman, Carl

AU - Wei, William I.

AU - Shah, Jatin P.

PY - 2007/12

Y1 - 2007/12

N2 - Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome.

AB - Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome.

KW - Basal cell carcinoma

KW - Head and neck

KW - International collaboration

KW - Skin cancer

KW - Skull base neoplasm

KW - Skull base/craniofacial surgery

KW - Squamous cell carcinoma

KW - Treatment outcome

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U2 - 10.1002/hed.20656

DO - 10.1002/hed.20656

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C2 - 17764086

AN - SCOPUS:38049004380

SN - 1043-3074

VL - 29

SP - 1136

EP - 1143

JO - Head and Neck

JF - Head and Neck

IS - 12

ER -

Craniofacial surgery for nonmelanoma skin malignancy: Report of an international collaborative study

Abstract

Keywords

UN SDGs

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