Cranberry juice constituents impair lymphoma growth and augment the generation of antilymphoma antibodies in syngeneic mice

Nira Hochman, Yael Houri-Haddad, Jennifer Koblinski, Larry Wahl, Maayan Roniger, Allan Bar-Sinai, Ervin I. Weiss, Jacob Hochman

Research output: Contribution to journalArticlepeer-review

Abstract

In addition to its nutritional value, cranberry juice has been effective in treating urinary tract infections. Various reports have also demonstrated its potential for inhibiting in vitro growth of transformed cell lines. Here we show that a fraction [nondialyzable material (NDM) of a molecular weight range 12,000-30,000 (NDM 12-30K)] derived from cranberry juice impairs in vitro growth and invasion through extracellular matrix of Rev-2-T-6 murine lymphoma cells. Furthermore, intraperitoneal injection of this fraction at nontoxic doses both inhibits the growth of Rev-2-T-6 tumors in vivo and enhances the generation of antilymphoma antibodies. These findings demonstrate the in vivo efficacy of cranberry components against malignant lymphoma in immune competent hosts.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalNutrition and Cancer
Volume60
Issue number4
DOIs
StatePublished - Jul 2008
Externally publishedYes

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