COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

Jochanan Benbassat; Paul Froom; Zvi Shimoni

doi:10.1016/j.ypmed.2022.107326

COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

Jochanan Benbassat^*, Paul Froom, Zvi Shimoni

^*Corresponding author for this work

School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65–2.44) (unadjusted) and 1.61 (1.29–2.03) after adjustment for the independent variables. This “healthy adherer effect” may confound observational assessments of the clinical efficacy of COVID-19 vaccines.

Original language	English
Article number	107326
Journal	Preventive Medicine
Volume	164
DOIs	https://doi.org/10.1016/j.ypmed.2022.107326
State	Published - Nov 2022

Keywords

COVID-19 vaccination
Efficacy of vaccine
Healthy adherer effect
Israel
Mortality
Retrospective cohort studies

Access to Document

10.1016/j.ypmed.2022.107326

Cite this

@article{b387fe42015b4daab3bf1dd333969f93,

title = "COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality",

abstract = "We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65–2.44) (unadjusted) and 1.61 (1.29–2.03) after adjustment for the independent variables. This “healthy adherer effect” may confound observational assessments of the clinical efficacy of COVID-19 vaccines.",

keywords = "COVID-19 vaccination, Efficacy of vaccine, Healthy adherer effect, Israel, Mortality, Retrospective cohort studies",

author = "Jochanan Benbassat and Paul Froom and Zvi Shimoni",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = nov,

doi = "10.1016/j.ypmed.2022.107326",

language = "אנגלית",

volume = "164",

journal = "Preventive Medicine",

issn = "0091-7435",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

AU - Benbassat, Jochanan

AU - Froom, Paul

AU - Shimoni, Zvi

PY - 2022/11

Y1 - 2022/11

N2 - We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65–2.44) (unadjusted) and 1.61 (1.29–2.03) after adjustment for the independent variables. This “healthy adherer effect” may confound observational assessments of the clinical efficacy of COVID-19 vaccines.

AB - We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65–2.44) (unadjusted) and 1.61 (1.29–2.03) after adjustment for the independent variables. This “healthy adherer effect” may confound observational assessments of the clinical efficacy of COVID-19 vaccines.

KW - COVID-19 vaccination

KW - Efficacy of vaccine

KW - Healthy adherer effect

KW - Israel

KW - Mortality

KW - Retrospective cohort studies

UR - http://www.scopus.com/inward/record.url?scp=85142402784&partnerID=8YFLogxK

U2 - 10.1016/j.ypmed.2022.107326

DO - 10.1016/j.ypmed.2022.107326

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 36332771

AN - SCOPUS:85142402784

SN - 0091-7435

VL - 164

JO - Preventive Medicine

JF - Preventive Medicine

M1 - 107326

ER -

COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this