COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality

Jochanan Benbassat*, Paul Froom, Zvi Shimoni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65–2.44) (unadjusted) and 1.61 (1.29–2.03) after adjustment for the independent variables. This “healthy adherer effect” may confound observational assessments of the clinical efficacy of COVID-19 vaccines.

Original languageEnglish
Article number107326
JournalPreventive Medicine
StatePublished - Nov 2022


  • COVID-19 vaccination
  • Efficacy of vaccine
  • Healthy adherer effect
  • Israel
  • Mortality
  • Retrospective cohort studies


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