COVID-19 vaccination and BA.1 breakthrough infection induce neutralising antibodies which are less efficient against BA.4 and BA.5 Omicron variants, Israel, March to June 2022

Limor Kliker, Neta Zuckerman, Nofar Atari, Noam Barda, Mayan Gilboa, Ital Nemet, Bayan Abd Elkader, Ilana S. Fratty, Hanaa Jaber, Ella Mendelson, Sharon Alroy-Preis, Yitshak Kreiss, Gili Regev-Yochay, Michal Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This work evaluated neutralising antibody titres against wild type (WT) SARS-CoV-2 and four Omicron variants (BA.1, BA.2, BA.4 and BA.5) in healthcare workers who had breakthrough BA.1 infection. Omicron breakthrough infection in individuals vaccinated three or four times before infection resulted in increased neutralising antibodies against the WT virus. The fourth vaccine dose did not further improve the neutralising efficiency over the third dose against all Omicron variants, especially BA.4 and BA.5. An Omicron-specific vaccine may be indicated.

Original languageEnglish
JournalEurosurveillance
Volume27
Issue number30
DOIs
StatePublished - 28 Jul 2022

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