TY - JOUR
T1 - COVID-19 infection in patients on long-term home parenteral nutrition for chronic intestinal failure
AU - Pironi, Loris
AU - Jezerski, Denise
AU - Sobocki, Jacek
AU - Lal, Simon
AU - Vanuytsel, Tim
AU - Theilla, Miriam
AU - Sasdelli, Anna S.
AU - Chambrier, Cecile
AU - Matysiak, Konrad
AU - Aimasso, Umberto
AU - Rasmussen, Henrik H.
AU - Jukes, Amelia
AU - Kunecki, Marek
AU - Seguy, David
AU - Schneider, Stéphane M.
AU - Daniels, Joanne
AU - Poullenot, Florian
AU - Mundi, Manpreet S.
AU - Matras, Przemysław
AU - Folwarski, Marcin
AU - Crivelli, Adriana
AU - Wyer, Nicola
AU - Ellegard, Lars
AU - Santarpia, Lidia
AU - Arvanitakis, Marianna
AU - Spaggiari, Corrado
AU - Lamprecht, Georg
AU - Guglielmi, Francesco W.
AU - Lezo, Antonella
AU - Layec, Sabrina
AU - Boluda, Esther Ramos
AU - Guz-Mark, Anat
AU - Gandullia, Paolo
AU - Cuerda, Cristina
AU - Osland, Emma
AU - Spagnuolo, Maria I.
AU - Krznaric, Zeljko
AU - Masconale, Luisa
AU - Chapman, Brooke
AU - Maíz-Jiménez, María
AU - Orlandoni, Paolo
AU - Martins da Rocha, Mariana Hollanda
AU - Virgili-Casas, M. Nuria
AU - Doitchinova-Simeonova, Maryana
AU - Czako, Laszlo
AU - Van Gossum, Andrè
AU - D'Antiga, Lorenzo
AU - Ee, Looi C.
AU - Warodomwichit, Daruneewan
AU - Taus, Marina
AU - Kolaček, Sanja
AU - Thibault, Ronan
AU - Verlato, Giovanna
AU - Serralde-Zúñiga, Aurora E.
AU - Botella-Carretero, José I.
AU - Aguayo, Pilar Serrano
AU - Olveira, Gabriel
AU - Chomtho, Sirinuch
AU - Pisprasert, Veeradej
AU - Moisejevs, Georgijs
AU - Murillo, Ana Zugasti
AU - Jáuregui, Ma Estrella Petrina
AU - Díez, Marta Bueno
AU - Jahit, Mohammad Shukri
AU - Densupsoontorn, Narumon
AU - Tamer, Ali
AU - Brillanti, Giorgia
AU - Joly, Francisca
N1 - Publisher Copyright:
© 2023 European Society for Clinical Nutrition and Metabolism
PY - 2023/6
Y1 - 2023/6
N2 - Background and aims: To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN). Methods: Period of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up. Results: Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths. Conclusions: In patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.
AB - Background and aims: To investigate the incidence and the severity of COVID-19 infection in patients enrolled in the database for home parenteral nutrition (HPN) for chronic intestinal failure (CIF) of the European Society for Clinical Nutrition and Metabolism (ESPEN). Methods: Period of observation: March 1st, 2020 March 1st, 2021. Inclusion criteria: patients included in the database since 2015 and still receiving HPN on March 1st, 2020 as well as new patients included in the database during the period of observation. Data related to the previous 12 months and recorded on March 1st 2021: 1) occurrence of COVID-19 infection since the beginning of the pandemic (yes, no, unknown); 2) infection severity (asymptomatic; mild, no-hospitalization; moderate, hospitalization no-ICU; severe, hospitalization in ICU); 3) vaccinated against COVID-19 (yes, no, unknown); 4) patient outcome on March 1st 2021: still on HPN, weaned off HPN, deceased, lost to follow up. Results: Sixty-eight centres from 23 countries included 4680 patients. Data on COVID-19 were available for 55.1% of patients. The cumulative incidence of infection was 9.6% in the total group and ranged from 0% to 21.9% in the cohorts of individual countries. Infection severity was reported as: asymptomatic 26.7%, mild 32.0%, moderate 36.0%, severe 5.3%. Vaccination status was unknown in 62.0% of patients, non-vaccinated 25.2%, vaccinated 12.8%. Patient outcome was reported as: still on HPN 78.6%, weaned off HPN 10.6%, deceased 9.7%, lost to follow up 1.1%. A higher incidence of infection (p = 0.04), greater severity of infection (p < 0.001) and a lower vaccination percentage (p = 0.01) were observed in deceased patients. In COVID-19 infected patients, deaths due to infection accounted for 42.8% of total deaths. Conclusions: In patients on HPN for CIF, the incidence of COVID-19 infection differed greatly among countries. Although the majority of cases were reported to be asymptomatic or have mild symptoms only, COVID-19 was reported to be fatal in a significant proportion of infected patients. Lack of vaccination was associated with a higher risk of death.
KW - COVID-19
KW - Epidemiology
KW - Home parenteral nutrition
KW - Intestinal failure
KW - Pandemic
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85151783368&partnerID=8YFLogxK
U2 - 10.1016/j.clnesp.2023.03.008
DO - 10.1016/j.clnesp.2023.03.008
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C2 - 37202049
AN - SCOPUS:85151783368
SN - 2405-4577
VL - 55
SP - 212
EP - 220
JO - Clinical Nutrition ESPEN
JF - Clinical Nutrition ESPEN
ER -