TY - JOUR
T1 - COVID-19 in advanced Duchenne/Becker muscular dystrophy patients
AU - Levine, Hagit
AU - Prais, Dario
AU - Aharoni, Sharon
AU - Nevo, Yoram
AU - Katz, Julia
AU - Rahmani, Eyal
AU - Goldberg, Lotem
AU - Scheuerman, Oded
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/7
Y1 - 2021/7
N2 - Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy. As a result of progressive muscle weakness, pulmonary function decreases during the second decade of life and lung disease contributes significantly to morbidity and mortality in these patients. Corticosteroids are the current standard of care for patients with DMD, despite known adverse effects such as obesity and immunosuppression. Over the past year (2020), the novel coronavirus (COVID-19/SARS-CoV2) outbreak has caused a global pandemic. Restrictive lung disease due to low lung volumes, chronic immunosuppressive treatment with corticosteroids, and obesity are potential risk factors that may contribute to a more severe course of the disease. Out of 116 Duchenne/Becker muscular dystrophy patients treated in our tertiary neuromuscular center, six patients with DMD and one with advanced Becker muscular dystrophy were found to be positive for COVID-19 infection. Two of the DMD patients were admitted for hospitalization, of whom one was dependent on daily nocturnal non-invasive ventilation. All patients recovered without complications despite obesity, steroid treatment and severe restrictive lung disease.
AB - Duchenne muscular dystrophy (DMD) is the most common childhood muscular dystrophy. As a result of progressive muscle weakness, pulmonary function decreases during the second decade of life and lung disease contributes significantly to morbidity and mortality in these patients. Corticosteroids are the current standard of care for patients with DMD, despite known adverse effects such as obesity and immunosuppression. Over the past year (2020), the novel coronavirus (COVID-19/SARS-CoV2) outbreak has caused a global pandemic. Restrictive lung disease due to low lung volumes, chronic immunosuppressive treatment with corticosteroids, and obesity are potential risk factors that may contribute to a more severe course of the disease. Out of 116 Duchenne/Becker muscular dystrophy patients treated in our tertiary neuromuscular center, six patients with DMD and one with advanced Becker muscular dystrophy were found to be positive for COVID-19 infection. Two of the DMD patients were admitted for hospitalization, of whom one was dependent on daily nocturnal non-invasive ventilation. All patients recovered without complications despite obesity, steroid treatment and severe restrictive lung disease.
KW - Becker muscular dystrophy
KW - COVID-19
KW - Duchenne muscular dystrophy
KW - Non-invasive ventilation
KW - Restrictive lung disease
UR - http://www.scopus.com/inward/record.url?scp=85107156439&partnerID=8YFLogxK
U2 - 10.1016/j.nmd.2021.03.011
DO - 10.1016/j.nmd.2021.03.011
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C2 - 34053847
AN - SCOPUS:85107156439
SN - 0960-8966
VL - 31
SP - 607
EP - 611
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
IS - 7
ER -